A Comparison Study of CBNAAT, Gene Xpert and Line Probe Assays in the Diagnosis of Tuberculosis in smear Negative Specimens

Tuberculosis (TB) is a serious and important public health issue to be addressed in India. Timely diagnosis of the drug resistance tuberculosis essential ensure initiate appropriate therapy. The detection resistant Mycobacterium (MTB) cases smear-negative clinical diagnosed pulmonary TB. A prospective case-control study was conducted on 473 samples received at tertiary care center from January 2019 December 2019. All specimens were processed for microscopy culture. CBNAAT- Gene Xpert LPA Genotype MTBDRplus (VER 2.0) used confirm samples. Among samples, 52% smear-positive, 48% smear-negative, 183 (43%) found culture-positive by Lowenstein Jensen medium (LJ) MGIT 960, 267 (63%) positive CBNAAT n= 216 (51%) TUB band. use CBNAAT-Gene Xpert, Line Probe Assay MTBDR plus(VER can done directly diagnostic performance are more specific detecting MTB specimens. This suggests that also helps MDR rapidly initiation earlier treatment.